Mon, Oct

(Reuters) - Pluristem Therapeutics said early clinical trials show its placenta-derived cell therapy is safe and improves quality of life in patients with peripheral artery disease, or PAD.

- Pluristem harvests cells from the placenta after a woman gives birth, so there is no ethical issue on using embryos.
- "We have proved we can use the placenta as a source for a product that doesn't require a match between the donor and patient,"

Pluristem's clinical trials showed patients experienced improvement in bloodstream, pain and quality of life for six months following a 20-minute session of injections.

Read more …Pluristem use the placenta as a source for stem cells, its therapy is promising for leg artery...

A team using StemCells Inc's nerve stem cells taken from aborted fetuses found that even a month after injury, the cells took up residence in the spine, proliferated and helped mice walk better.

- "These exciting results demonstrate an expanded window of opportunity for human neural stem cell intervention in spinal cord injury,"
- The cells migrated through the spine, grew and began to function -- 64% of the stem-cell-treated mice walked better, compared to 44% of mice treated with ordinary cells and 20% of placebo-treated mice.

About 1.25 million Americans have chronic spinal cord injuries. "This latest study provides additional evidence that the use of our human neural stem cells may be a viable treatment approach for them,".

Read more …Stem cells take up residence in mice with spine injury and help them walk better - Reuters...

The experts said they were particularly concerned about a firm in Germany called XCell-Center and about Beike, which offers stem cell treatments for a range of conditions including brain injury, cerebral palsy, multiple sclerosis, spinal cord injury and optic nerve damage.

- A spokesman for XCell said in a statement that its stem cell preparations are made from bone marrow and intended for "autologous" use, or use by patients from whom they came.
- Beike Biotech said in a statement that all its stem cells are administered by experienced physicians who work in and for leading hospitals in China.

Stem cells are standard treatments for leukemias and a few other genetic diseases, but their use in treating other conditions such as Parkinson's, spinal injury or optic nerve damage is as yet unproven.

Read more …Stem Cell therapy companies in China and Germany criticized by British experts warning of the...

"In an earlier study, we observed that middle-aged children of long-lived siblings have lower thyroid function compared to controls from the general population,"
"In the current study, we sought to assess whether in the generation of the long-lived siblings low thyroid function was related to enhanced survival of the parents of the siblings as well,"

After rating the longevity of these siblings' parents, the team analyzed the thyroid hormones in the siblings' blood. The two sets of values appeared to be strongly linked, supporting previous findings of heritability in decreased thyroid functioning and its relationship to long life.

Read more …Researchers link longevity with thyroid activity but other factors could be the cause - Reuters...

Chuck Murry, professor at the University of Washington, talks about his lab's research in regenerating new heart tissue out of stem cells.

- the building blocks of heart muscles, we can make the cells of blood vessels, connective tissue cells.
- progress in getting them to self assemble and organize a coherent tissue.
- we believe that by growing new heart muscle we can regress heart failure.
- we've shown that if we can transplant these in animals that have had a heart attack we can prevent them from developing heart failure.


Read more …Researcher talks about his lab's research in regenerating new heart tissue out of stem cells -...

Scientists in Romania say they have discovered a type of cell called telocites, which may be similar to stem cells.

- first found in the pancreases and then in 15 other organs.
- they hope that telocites can play a role in the regeneration and repair of the body because they are related to stem cells.

Read more …Scientists in Romania discover cell called telocites, which may help regenerate and repair the...

- Experts say it's time to recognize aging as a condition that can be treated and delayed.
- Because aging is not viewed as a disease scientists are hampered by regulators who license for diseases.
- By finding the genes thought to help determine longevity, scientists think they may be able to mimic their action to extend health span.

Read more …Specialists in aging are lobbying the FDA to consider redefining aging as a disease - Reuters...

- Scientists in Germany and Switzerland found that an enzyme called COX-2 triggers development of fat cells to become brown fat, instead of white fat.
- Once activated by cold temperatures, brown fat burns calories faster than regular fat.
- Mice who were genetically engineered to produce high levels of COX-2 burned energy faster and were protected from obesity.

Read more …Scientists now trying to use stem cells to generate brown fat cells to help speed up calorie burn....

- The findings suggest that women with Parkinson's could serve as their own stem cell donors.
- The endometrial stem cells generate less of an immune system rejection and women shed them naturally every month.
- The researchers transformed stem cells into dopamine-producing nerve cells like those in the brain.
- Parkinson's is caused by the destruction of brain cells that produce dopamine, an important message-carrying chemical involved in movement.

Read more …Stem cells from the lining of a woman's uterus transformed into brain cells in mice whose brains...

(HealthDay News) - Researchers at the U.S. National Institutes of Health have discovered bone-generating stem cells in the spine, at the end of the shins and in cartilage-rich areas of other bones.
- "Now researchers can explore ways to harness these cells so that ultimately they might be used to repair damaged or malformed bone."
- The U.S. National Institutes of Health has more about stem cells.

Read more …U.S. National Institutes of Health have discovered bone-generating Stem Cells in the spine - CBC...

- The differences in DAF-16 corresponded to differences in longevity, stress resistance and immunity between the four species, with higher levels of DAF-16 activity correlating to longer life, increased resistance and better immunity against some infections.

Read more …Scientists find specific gene DAF-16 is strongly linked to lifespan, immunity and disease...

Longevity and Premature Aging; the existence of the decades old practice of wearing a person down and trying to induce premature aging through high levels of stress and sleep deprivation has been denied by the medical community for decades, and so has psychological harassment.
- During a person’s sleep cycle the body goes into DNA repair mode so sleep deprivation can accelerate premature aging.
- It is the reverse of trying to stimulate the sirtuin genes for increased DNA repair and longevity.

Good large cholesterol is linked to inheritance but exercise increases and is linked to good cholesterol; diet is linked to reducing bad cholesterol. Calorie restriction which triggers the body’s survival mode response, stimulates the Sirtuin Genes, is linked to longevity but resveratrol also stimulates the Sirtuin Genes without the calorie restriction.
- Cholesterol; good large cholesterol has been linked to people living to 100 years old.
- Sirtuin Genes; kick in when the body is in survival mode and increase DNA repair and prevent cell death.
- Insulin; low levels are linked to longevity in research studies.

Clevers said the advantage offered by the "mother" stem cell finding would be that they could grow skin from its original basis -- allowing it to be "real new skin" with moisture from sebaceous glands and the ability to grow hair.
- "This is the mother of all the stem cells in the skin -- it makes all the other stem cells,"
- their discovery could dramatically improve skin treatments for victims of serious wounds and burns.
Read more …Stem Cells: Scientists find "mother" of all skin cells - Reuters (article link)
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